Connect with us

Anglais

Trying to bridge the ‘genomic divide’: Lack of Indigenous data a challenge for researchers

admin

Published

on


A prominent U.S. senator turned to genetic testing last month to try to prove her claim that she had Indigenous ancestry.

But in assessing Elizabeth Warren’s DNA, the geneticists were forced to use samples from Mexico, Peru and Colombia because there were no samples from American Indigenous peoples in the reference databases. 

Because the data is missing, Indigenous geneticists Krystal Tsosie of Vanderbilt University and Matthew Anderson of Ohio State University argue that Warren’s test results, which showed Native American ancestry six to 10 generations ago, are a reach.

Many more researchers have joined the discussion regarding Warren’s DNA test results, weighing in on the problems inherent in using genetic databases to unearth Indigenous ancestry.

Indigenous data is missing because « Native American groups within the U.S. have not chosen to participate in recent population genetic studies, » wrote Carlos Bustamante, the geneticist studying Warren’s DNA. That information gap for Indigenous groups exists around the world, including Canada. 

« The Warren news was a distraction from the real work, » said Laura Arbour, one of the lead scientists for the Silent Genome project recently funded by Genome Canada and Genome British Columbia. 

Arbour and her colleagues are trying to develop strategies to better engage Indigenous communities in genomic research.

She describes a growing « genomic divide » that reflects the apparently insatiable appetite among people with a European background to give their DNA to large databases in return for predictions regarding future health and well-being.

Precision medicine

Bridging this « genomic divide » will allow Indigenous people to benefit from a future with precision medicine, says Arbour.

The term precision medicine refers to the use of genomic data to predict which drug will work best for each person.

But precision medicine cannot serve Indigenous people if their reference data is missing.

The lack of representation of Indigenous genomes in large databases reflects a general wariness in that group caused in part by historical cases of genetic research gone wrong. 

One study considered by leading geneticists including Roderick McInnes, former institute director in the Canadian Institutes of Health Research, as a game changer involved the Nuu-chah-nulth First Nations on Vancouver Island.

The Nuu-chah-nulth have a high frequency of rheumatoid arthritis. The research team collected DNA samples from approximately half of the First Nations members to study the genetic basis for the disorder.

The genetic determinants of rheumatoid arthritis weren’t found, but that wasn’t the big problem. Researchers sent the DNA samples to external facilities for genetic ancestry studies without the knowledge or consent of the participants.

That action created concern around privacy and possible exploitation through the use of the genetic data for commercial gain, Tsosie and Anderson wrote in a piece posted on The Conversation.

Positive relationships

On the other hand, there are examples of positive relationships between Indigenous groups and non-Indigenous genetic researchers. 

Members of the Gitxsan nation in British Columbia, for instance, told Arbour and her colleagues about the high prevalence of sudden cardiac death in their community.

The Gitxsan not only initiated the research into the genetic cause for this disease but also helped supervise the work through advisory and governance committees.

When geneticists were assessing U.S. Senator Elizabeth Warren’s DNA, they had to use samples from Mexico, Peru and Colombia because there were no samples from American Indigenous peoples in the reference databases. (Charles Krupa/Associated Press)

With that co-operative relationship, the research team found the genetic basis for the prevalence of Long QT syndrome, which can cause sudden cardiac death, in the Gitxsan. A gene mutation was found to be responsible for disrupting normal cardiac rhythm. The Gitxsan could then be effectively treated for Long QT syndrome after that discovery.  

Arbour also sees a need to customize the practices for DNA collection in Indigenous communities so that they maintain control.

One little-known aspect about most genetic testing projects, such as the 1000 Genomes Project or 23andMe, is that they, not the donor, retain ownership of the sample.

Indigenous leaders don’t want this to happen in studies of their people.

DNA obtained from an Indigenous individual should be considered « on loan » to the researcher just for the purpose of the specific research project, says Arbour. Ownership of the sample should be retained by the individual with the future potential to be stored in a « tribal-controlled DNA bank, » she says.

Calls for Indigenous leadership

Indigenous leaders have long recognized the need for Indigenous scientists to take ownership of the research conducted with their DNA.

Writing in the Hill Times last month, Natan Obed, president of the Inuit Tapiriit Kanatami, a national, non-profiit organization representing 60,000 Inuit, said that « Inuit are the most researched people in the world — yet with colonial approaches to research … our role is imagined as marginal and of little value. »

He also recently renewed his call for Inuit leadership in the three major Canadian research agencies: the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada and the Social Sciences and Humanities Research Council of Canada.  

Laura Arbour, one of the lead scientists for the Silent Genome project recently funded by Genome Canada and Genome British Columbia, and her colleagues are trying to develop strategies to better engage Indigenous communities in genomic research. (Brad Lyle, Genome BC)    

Building capacity for Indigenous leadership in genomic research takes time. 

But real change could come through the work of programs like SING, which stands for the Summer Internship for Indigenous Peoples in Genomics.

This educational program initiated at the University of Illinois Urbana-Champaign in 2011 and sponsored by multiple agencies including the National Institutes of Health was geared primarily for Indigenous students in a university undergraduate or graduate degree program in the U.S. but has since spread to Canada and New Zealand. 

The SING workshops aim to give Indigenous students interested in genetic science additional skills and knowledge that would help them move into advisory and leadership roles within genetic research. The workshops of approximately 20 participants have been held annually at multiple U.S. university venues, most recently in Seattle earlier this year.

Katrina Claw, a former SING participant and now a leader of the program in the U.S., says there have been participants from 44 First Nations, including mostly students who are interested in genomic, social and political sciences. 

The SING training workshops include basic scientific methods in DNA sequencing and analysis along with tutorials on the principles of informed consent and ethics relating to DNA data sharing. 

Faculty positions

The Indigenous leader of SING Canada, Kim TallBear, an associate professor in the Faculty of Native Studies at the University of Alberta, says that genomics research must also be taught with the view of correcting the history of disciplinary mistakes made by scientists.

A significant proportion of SING participants enter the program with a background in genomic science or the social and political sciences and with the intention of learning about Indigenous genomics from a « bioethical and decolonizational perspective, » said TallBear.

The goal of the SING workshops is starting to be realized. According to TallBear, Anderson is another great example of someone of Indigenous descent who started with SING as a graduate student, came up through the ranks to become an assistant professor and is already leading discussions around genomic research in Indigenous communities.



Source link

قالب وردپرس

Anglais

These US entities partnered with the Wuhan Institute of Virology — time for a criminal investigation?

admin

Published

on

By

(Natural News) The Wuhan Institute of Virology from which the Wuhan coronavirus (COVID-19) is believed to have “escaped” has a number of questionable partnerships that are worth looking into in light of the pandemic.

Most of them are universities, including the University of Alabama, the University of North Texas, and Harvard University. There is also the EcoHealth Alliance, the National Institutes of Health (NIH), and the National Wildlife Federation.

While the relationships between these entities and the Wuhan Institute of Virology may be completely innocent, there is no way to really say for sure without a proper investigation. And this is exactly what Secretary of State Mike Pompeo is calling for, as is the nation of Australia.

Pompeo and the folks down under, along with millions of Americans, would really like to know the true origins of the Wuhan coronavirus (COVID-19). An increasing number of people simply are not buying the narrative that the novel virus originated in bat soup at a Chinese wet market, and this even includes mainstream media outlets like Fox News.

The only way to really determine what was going on at the Wuhan Institute of Virology, and who else might have been involved. is to open the place up for an international investigation. But communist China is against this, of course, accusing Australia of “petty tricks” and collusion with the United States.

“Overnight, I saw comments from the Chinese Foreign Ministry talking about a course of activity with respect to Australia who had the temerity to ask for investigation,” Pompeo is quoted as saying in response to China’s aggression against a proposed investigation.

“Who in the world wouldn’t want an investigation of how this happened to the world?” he added.

As the U.S. aims to get back on track economically speaking, Pompeo believes that now is the time to hold communist China, the Wuhan Institute of Virology, and whoever else may have been involved accountable for unleashing this pandemic on the world.

“Not only American wealth, but the global economy’s devastation as a result of this virus,” Pompeo further stated. “There will be a time for this. We will get that timing right.”

Continue Reading

Anglais

New U.S. analysis finds that lab in Wuhan, China was “most likely” origin of coronavirus release

admin

Published

on

By

(Natural News) While American Leftists and most of the Democrat Party continue to serve as apologists for the Chinese Communist regime over its role in creating and then perpetuating the coronavirus pandemic, a new U.S. government analysis concludes that COVID-19 “most likely” escaped from a lab near Wuhan city.

The Washington Times reports that the analysis cataloged evidence linking the outbreak to the Wuhan lab and has found that other explanations for the origins of the virus are not as credible.

The paper reported:

The document, compiled from open sources and not a finished product, says there is no smoking gun to blame the virus on either the Wuhan Institute of Virology or the Wuhan branch of the Chinese Center for Disease Control and Prevention, both located in the city where the first outbreaks were reported.

However, “there is circumstantial evidence to suggest such may be the case,” the paper says.

“All other possible places of the virus’ origin have been proven to be highly unlikely,” said the report, a copy of which was obtained by the Times.

ChiCom officials have claimed that the virus’ origin is unknown. However, Beijing initially stated that coronavirus came from animals at a “wet market” in Wuhan where exotic meats are butchered and sold in disgusting conditions.

Chinese officials claim that COVID-19 went from bats to animals sold in the market last year, then infected humans.

U.S. intelligence officials have increasingly dismissed that explanation, however, as attention has begun to focus on evidence suggesting that Chinese medical researchers were working with coronavirus in the country’s only Level 4 facility, which is in Wuhan.

U.S. Army Gen. Mark A. Milley, chairman of the Joint Chiefs of Staff, has said that intelligence agencies are investigating whether the virus escaped from a lab or was the result of a naturally occurring outbreak, but that analysts have ruled out reports that COVID-19 was manmade.

‘The most logical place to investigate the virus origin has been completely sealed off’

“At this point, it’s inconclusive, although the weight of evidence seems to indicate natural,” the general said on April 14, “but we don’t know for certain.”

The analysis said that the wet market explanation does not ring true because the first human diagnosis of coronavirus was made in someone who had no connection to the wet market in question. And according to Chinese reports, no bats were sold at that particular market.

At the same time, several questionable actions and a growing paper trail provide clues that the virus actually escaped from a lab, even as China begins to clamp down on those information streams.

Continue Reading

Anglais

The biggest media lies about the coronavirus: Origins, treatments and vaccines

admin

Published

on

By

(Natural News) If there is one thing that most everyone can agree on concerning the Wuhan coronavirus (COVID-19) pandemic, it is the fact that there is no shortage of conflicting information out there about the nature of it. And the mainstream media is certainly doing its part to steer the narrative as part of a larger agenda, using plenty of misinformation along the way.

The following are among the most commonly parroted lies about the Wuhan coronavirus (COVID-19) that aim to distort the facts and deceive you into believing falsehoods about this pandemic:

Media LIE: The virus is not man-made

From the very beginning of this thing, the official narrative was that the Wuhan coronavirus (COVID-19) came from a Chinese wet market where bats and other “exotic” animals are sold as meat. But the world later learned that it actually more than likely “escaped” from the Wuhan Institute of Virology.

The mainstream media and social media platforms went nuts trying to censor this information and even called it  “fake news.” But eventually it became undeniable that bat soup was not responsible for spreading the Wuhan coronavirus (COVID-19) around Wuhan and eventually to the rest of the world – hence why we continue to call it the Wuhan coronavirus rather than just COVID-19.

We have even seen attempts by the media machine at making the Wuhan coronavirus (COVID-19) a racial issue because there are supposedly more “people of color” coming down with it than people with fair skin, which further detracts attention away from the source of this virus.

Media LIE: Hydroxychloroquine is extremely dangerous and doesn’t work

The minute that President Donald Trump announced that hydroxychloroquine may be an effective, and very inexpensive, remedy for the Wuhan coronavirus (COVID-19), the mainstream media immediately began decrying this claim as fake news, even though Anthony Fauci himself praised hydroxychloroquine back in 2013 under Barack Obama as being some type of “miracle cure” for SARS (severe acute respiratory syndrome).

There have even been studies conducted that were designed to intentionally smear the drug as both ineffective and dangerous, though one in particular purposely left out zinc, which appears to be a critical co-factor in supporting the effectiveness of hydroxychloroquine – in other words, politics as usual.

Media LIE: Only a vaccine can save us from coronavirus

Many politicians and public health officials are parroting the lie that the only way America can come out of lockdown and go back to “normal” is to get vaccinated with some future vaccine for the Wuhan coronavirus (COVID-19) that does not even yet exist. A vaccine, we are repeatedly told, is the only thing, or perhaps some new “blockbuster” antiviral drug, that can cure the world of this scourge and make everything happy and wonderful once again.

Meanwhile, not a peep is being made about things like intravenous (IV) high-dose vitamin C, which is being successfully used in other countries to stem the tide of infections without the need for new drugs and vaccines.

By omission, nutrition is pointless

Speaking of natural approaches to overcoming the Wuhan coronavirus (COVID-19) that are being systematically ignored by the mainstream media and most in politics, have you heard anyone mention the importance of nutrition in all of this? We did not think so, and this is intentional.

Regular readers of this site over the years should know by now that the single-most important thing you need to do to stay healthy besides exercising regularly is to feed your body the nutrition it needs to naturally ward off illnesses, including those associated with the Wuhan coronavirus (COVID-19).

Research compiled by the Lewin Group reveals that nutritional remedies such as calcium, vitamin D, folate, omega-3 fatty acids, lutein, zeaxanthin, and more all play a critical role in fortifying the immune system, which, if properly nourished, should have little problem fending off disease.

Continue Reading

Chat

Technologie1 mois ago

Service de traduction de documents PDF en ligne en toute simplicité et abordable – Protranslate est disponible 24 heures par jour et est offert en plus de 60 langues

Anglais3 mois ago

These US entities partnered with the Wuhan Institute of Virology — time for a criminal investigation?

Anglais3 mois ago

New U.S. analysis finds that lab in Wuhan, China was “most likely” origin of coronavirus release

Anglais3 mois ago

The biggest media lies about the coronavirus: Origins, treatments and vaccines

Actualités3 mois ago

Andrew Scheer demande une mise à jour économique d’ici l’été

Actualités3 mois ago

Plusieurs tours cellulaires incendiées au cours des derniers jours

Actualités3 mois ago

Danemark: le déconfinement ne semble pas avoir accéléré la propagation de la COVID-19

Actualités3 mois ago

Le maire de Joliette peu rassuré par le déconfinement en cours

Actualités3 mois ago

Un homme de 61 ans tué à l’arme blanche à Montréal

Actualités3 mois ago

Pas de déconfinement pour les commerces de Kahnawake

Actualités3 mois ago

Quel avenir pour les restos-bars sportifs?

Actualités3 mois ago

Éclosions de COVID-19 à l’Hôpital Pierre-Boucher de Longueuil

Anglais3 mois ago

Nobel Prize winner who discovered HIV says coronavirus was definitely released from Wuhan lab, contains HIV DNA

Anglais3 mois ago

Must-see infographic: The “Death Science” Depopulation Trifecta … Biological weapons, vaccines and 5G, all aimed at humanity

Anglais3 mois ago

Dead coronavirus victims found stacked in U-haul trucks in front of New York City funeral home

Anglais3 mois ago

Bill and Melinda Gates are preppers: Couple began storing food in their home years ago in case of a pandemic

Anglais3 mois ago

Nearly half of severe coronavirus cases involve neurological complications

Anglais3 mois ago

Global survey of deaths reveals coronavirus kills 10% of those diagnosed with symptoms, making it 100 times deadlier than flu

Anglais3 mois ago

Homeland security scientist confirms that natural sunlight kills coronavirus

Anglais3 mois ago

Big Pharma is rigging everything to make sure approved coronavirus “treatments” don’t actually work at all, while things that do work are discredited or criminalized

Anglais2 années ago

Body found after downtown Lethbridge apartment building fire, police investigating – Lethbridge

Styles De Vie2 années ago

Salon du chocolat 2018: les 5 temps forts

Anglais2 années ago

This B.C. woman’s recipe is one of the most popular of all time — and the story behind it is bananas

Anglais2 années ago

27 CP Rail cars derail near Lake Louise, Alta.

Anglais2 années ago

Man facing eviction from family home on Toronto Islands gets reprieve — for now

Santé Et Nutrition2 années ago

Gluten-Free Muffins

Santé Et Nutrition2 années ago

We Try Kin Euphorics and How to REALLY Get the Glow | Healthyish

Anglais2 années ago

Ontario’s Tories hope Ryan Gosling video will keep supporters from breaking up with the party

Anglais1 année ago

A photo taken on Toronto’s Corso Italia 49 years ago became a family legend. No one saw it — until now

Anglais2 années ago

Condo developer Thomas Liu — who collected millions but hasn’t built anything — loses court fight with Town of Ajax

Styles De Vie2 années ago

Renaud Capuçon, rédacteur en chef du Figaroscope

Anglais1 année ago

This couple shares a 335-square-foot micro condo on Queen St. — and loves it

Mode2 années ago

Paris : chez Cécile Roederer co-fondatrice de Smallable

Anglais2 années ago

Ontario Tories argue Trudeau’s carbon plan is ‘unconstitutional’

Anglais2 années ago

100 years later, Montreal’s Black Watch regiment returns to Wallers, France

Anglais2 années ago

Trudeau government would reject Jason Kenney, taxpayers group in carbon tax court fight

Technologie1 année ago

YouTube recommande de la pornographie juvénile, allègue un internaute

Styles De Vie2 années ago

Ford Ranger Raptor, le pick-up roule des mécaniques

Affaires2 années ago

Le Forex devient de plus en plus accessible aux débutants

Anglais2 années ago

Province’s push for private funding, additional stops puts Scarborough subway at risk of delays

Trending